Checkpoint inhibition and infectious diseases: a good thing?
MS Abers, MS Lionakis, DP Kontoyiannis - Trends in Molecular Medicine, 2019 - cell.com
The mammalian immune system has evolved the capacity to detect and destroy tumor cells.
Tumors utilize multiple strategies to evade host immune surveillance, including the induction …
Tumors utilize multiple strategies to evade host immune surveillance, including the induction …
[HTML][HTML] Emerging concepts of adaptive immunity in leprosy
S Sadhu, DK Mitra - Frontiers in Immunology, 2018 - frontiersin.org
Leprosy is a chronic intracellular infection caused by the acid-fast bacillus, Mycobacterium
leprae. The disease chiefly affects the skin, peripheral nerves, mucosa of the upper …
leprae. The disease chiefly affects the skin, peripheral nerves, mucosa of the upper …
Immunological biomarkers of subclinical infection in household contacts of leprosy patients
EA Queiroz, NI Medeiros, RT Mattos, APM Carvalho… - Immunobiology, 2019 - Elsevier
Hansen's disease (or leprosy) still persists as a serious public health issue. Its diagnosis is
based primarily on the detection of clinical signs that are characteristic of the disease …
based primarily on the detection of clinical signs that are characteristic of the disease …
Functional biomarker signatures of circulating T-cells and its association with distinct clinical status of leprosy patients and their respective household contacts
PHF Marçal, RS Gama, LBP de Oliveira… - Infectious Diseases of …, 2020 - mednexus.org
Background: Leprosy is a chronic infectious disease classified into two subgroups for
therapeutic purposes: paucibacillary (PB) and multibacillary (MB), closely related to the host …
therapeutic purposes: paucibacillary (PB) and multibacillary (MB), closely related to the host …
ZAP-70, CTLA-4 and proximal T cell receptor signaling in cows infected with Mycobacterium avium subsp. paratuberculosis
FL Leite, LB Eslabão, B Pesch, JP Bannantine… - Veterinary immunology …, 2015 - Elsevier
Paratuberculosis is a chronic intestinal disease of ruminant animals caused by
Mycobacterium avium subsp. paratuberculosis (MAP). A hallmark of paratuberculosis is a …
Mycobacterium avium subsp. paratuberculosis (MAP). A hallmark of paratuberculosis is a …
Leprosy as a model to understand cancer immunosurveillance and T cell anergy
AJ Park, T Rendini, F Martiniuk… - Journal of Leucocyte …, 2016 - academic.oup.com
Leprosy is a disease caused by Mycobacterium leprae that presents on a spectrum of both
clinical manifestations and T cell response. On one end of this spectrum, tuberculoid leprosy …
clinical manifestations and T cell response. On one end of this spectrum, tuberculoid leprosy …
[HTML][HTML] Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis
P Geng, X Zhao, L Xiang, Y Liao, N Wang, J Ou, G Xie… - Plos one, 2014 - journals.plos.org
Background and Purpose Previous studies concerning the role of CD86 polymorphisms
(rs1129055 and rs17281995) in cancer fail to provide compelling evidence. The aim of this …
(rs1129055 and rs17281995) in cancer fail to provide compelling evidence. The aim of this …
[HTML][HTML] Presence of senescent and memory CD8+ leukocytes as immunocenescence markers in skin lesions of elderly leprosy patients
PHL Da Silva, KKG De Castro, MA Mendes… - Frontiers in …, 2021 - frontiersin.org
Leprosy is an infectious disease that remains endemic in approximately 100 developing
countries, where about 200,000 new cases are diagnosed each year. Moreover …
countries, where about 200,000 new cases are diagnosed each year. Moreover …
Apoptotic activity and Treg cells in tissue lesions of patients with leprosy
JAS Quaresma, PC Esteves, TL de Sousa Aarão… - Microbial …, 2014 - Elsevier
In order to understand the apoptotic response and the participation of Treg cells in the
spectral clinical evolution of leprosy, this study evaluated the immunohistochemical …
spectral clinical evolution of leprosy, this study evaluated the immunohistochemical …
[HTML][HTML] Immune checkpoints in leprosy: immunotherapy as a feasible approach to control disease progression
HR Lima, TH Gasparoto… - Frontiers in …, 2017 - frontiersin.org
Leprosy remains a health problem in several countries. Current management of patients
with leprosy is complex and requires multidrug therapy. Nonetheless, antibiotic treatment is …
with leprosy is complex and requires multidrug therapy. Nonetheless, antibiotic treatment is …