David De Wied had a fundamental interest in the brain and behaviour, with a particular
interest in the interface between cognition and emotion, and how impairments at this …

Although glutamate is a simple molecule, its actions in the limbic system and areas
concerning anxiety are complex and widespread. These actions are mediated through …

Anxiety and stress-related disorders, namely posttraumatic stress disorder (PTSD),
generalized anxiety disorder (GAD), obsessive–compulsive disorder (ODC), social and …

Oxidative stress caused by reactive species, including reactive oxygen species, reactive
nitrogen species, and unbound, adventitious metal ions (eg, iron [Fe] and copper [Cu]), is an …

In order to localise the often reported anxiolytic action of N-methyl-D-aspartate (NMDA)
receptor antagonists, 2-amino-7-phosphonoheptanoic acid (AP7) was injected into the …

NMDA receptor antagonists have been shown to be anxiolytic in animal models of anxiety,
although they have not been tested extensively. These compounds bind to several specific …

Although noncompetitive NMDA receptor antagonists have shown an anxiolyticlike profile in
several studies, such effects have not been observed consistently. Previous studies with …

Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and
have severe health and socio-economic implications. Despite the availability of a number of …

It is considered that nitric oxide (NO) is one of the most interesting research subjects.
Because the actual role of NO in the mechanism of anxiety is still unclear, in this study, the …

The effects of the competitive N-methyl-D-aspartate (NMDA) antagonists CPP (5 & 10 mg/kg)
and NPC 12626 (25 & 40 mg/kg) and the noncompetitive NMDA antagonists phencyclidine …