Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

MicroRNA (miR)-155 is a critical player in both innate and adaptive immune responses. It
can influence CD4+ T cell lineage choice. To clarify the role of miR-155 in CD4+ CD25+ …

The suppressor of cytokine signaling (SOCS) family of intracellular checkpoint inhibitors has
received little recognition compared to other checkpoint inhibitors. Two members of this …

Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system
(CNS). Despite a complex pathogenesis, it appears that an imbalanced immune system …

Multiple sclerosis (MS) and its animal model of experimental autoimmune encephalomyelitis
(EAE) are characterized by focal inflammatory infiltrates into the central nervous system …

The suppressor of cytokine signaling (SOCS) family of intracellular proteins has a vital role
in the regulation of the immune system and resolution of inflammatory cascades. SOCS1 …

The maintenance of immune homeostasis requires regulatory T cells (Treg cells). Here we
found that Treg cell–specific ablation of Ubc13, a Lys63 (K63)-specific ubiquitin-conjugating …

SOCS are a family of negative inhibitors of the molecular cascades induced by cytokines,
growth factors and hormones. At molecular level, SOCS proteins inhibit the kinase activity of …

Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes,
and their development is intricately connected to the disruption of the JAK-STAT signaling …