Mutations in leucine-rich repeat kinase 2 (LRRK2) are commonly implicated in the
pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates …

The identification of thousands of proteins and their relative levels of expression has
furthered understanding of biological processes and disease and stimulated new systems …

The evolution of mass spectrometry (MS) and analytical techniques has led to the demand
for proteome analysis with high proteome coverage in single-shot measurements. Focus has …

Polyphenols are one of the most important metabolites in tea due to their unique biological
activities and health benefits, arousing great attention of researchers to investigate …

Proteome profiling is a powerful tool in biological and biomedical studies, starting with
samples at bulk, single-cell, or single-cell-type levels. Reliable methods for extracting …

The leaves and branches of Chimonanthus salicifolius and Chimonanthus zhejiangensis
are the base ingredients of Shiliang tea. In this study, proteomics and metabolomics were …

Genetic loss of Agpat2 in humans and mice results in congenital generalized lipodystrophy
with near-total loss of adipose tissue and predisposition to develop insulin resistance …

AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol
(TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT …

Digital microfluidics (DMF) is a technology suitable for bioanalytical applications requiring
miniaturized, automated, and multiplexed liquid handling. Its use in LC-MS-based …

Neuroblastoma accounts for 15% of cancer-related deaths in children, highlighting an unmet
need for novel therapies. Selinexor is a small molecule inhibitor of XPO1. XPO1 shuffles …