Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Emerging evidence shows that the biomechanical environment is required to support cancer
stem cells (CSCs), which play a crucial role in drug resistance. However, how …

Lung cancer is one of the common malignant tumors that threaten human life with serious
incidence and high mortality. According to the histopathological characteristics, lung cancer …

The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

Significant changes in cell stiffness, contractility, and adhesion, ie, mechanotype, are
observed during a variety of biological processes. Whether cell mechanics merely change …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

Progression through dissemination to tumor-surrounding tissues and metastasis
development is a hallmark of cancer that requires continuous cell-to-cell interactions and …