Some of the best biomarkers of age-related cognitive decline are closely linked to synaptic
function and plasticity. This review highlights several age-related synaptic alterations as they …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet
current therapeutic treatments are inadequate due to a complex disease pathogenesis. The …

Polyphenols are the most abundant components of our daily food, occupying the major
portion of naturally occurring phytochemicals in plants. Currently, polyphenols have …

Background Proanthocyanidin is a polyphenolic bioflavonoid with known antioxidant activity.
Some flavonoids have a modulatory effect on [Ca 2+] i. Although proanthocyanidin extract …

Alzheimer's disease (AD) is a neurodegenerative brain disorder, which causes cognitive
impairments and memory loss. Currently prescribed drugs for AD provide only symptomatic …

Abstract Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is a potent
natural antioxidant. However, effects of C3G on glutamate-induced [Zn 2+] i increase and …

Flavonoids have an ability to suppress various ion channels. We determined whether one of
flavonoids, cyanidin-3-glucoside, affects adenosine 5'-triphosphate (ATP)-induced calcium …

Ethnopharmacological relevance The aqueous extract of the plant Malmpyrum pratense
(Mp), is widely used in traditional medicine as a sedative, yet the biological basis of its action …

Phenolic compounds affect intracellular free Ca 2+ concentration ([Ca 2+] i) signaling. The
study examined whether the simple phenolic compound octyl gallate affects ATP-induced …