The unraveling of cellular apoptosis machinery provides novel targets for cancer treatment,
and gene therapy targeting this suicidal system has been corroborated to cause …

The development of effective treatments that enable many patients suffering from cancer to
be successfully cured is highly demanded. Angiogenesis, which is a process for the …

Controlled-release systems capable of responding to external stimuli and/or unique internal
environments have received great interests in site-specific gene and/or drug delivery. In this …

Background: An essential prerequisite for successful gene therapy is the development of
safe and efficient gene delivery carriers. For this purpose, cationic polymers have been …

In the past decades, the mainstay of systemic therapy for solid and haematological
malignancies was chemotherapy; nevertheless this modality has the drawbacks such as …

The efficient delivery of therapeutic genes into cells of interest is a critical challenge to broad
application of non-viral vector systems. In this research, a novel TPGS-b-(PCL-ran-PGA) …

The controlled release of siRNA or DNA complexes from cationic polymers is an important
parameter design in polymer-based delivery carriers. In this work, we use the self-catalyzed …

Biomaterials coated polymer/DNA complexes are developed as an efficient non-viral gene
delivery system. It is able to circumvent the changes of various biophysical properties of the …

An increasing body of evidence suggests that ribosomal proteins may have ribosome-
independent functions and may be involved in various physiological and pathological …

In this present work we describe a poly (lactic-co-glycolic acid)(PLGA) nanoparticle
formulation for intracellular delivery of plasmid DNA. This formulation was developed to …