The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …

Inflammation has been linked to multiple degenerative and acute diseases as well as the
aging process. Moreover, mitochondrial alterations play a central role in these processes …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

Mitochondria are inevitable sources for the generation of mitochondrial reactive oxygen
species (mtROS) due to their fundamental roles in respiration. mtROS were reported to be …

Microglia are the resident immune cells of the brain and play major roles in central nervous
system development, maintenance, and disease. Brain insults cause microglia to proliferate …

Mitochondrial dysfunction has been associated with age‐related diseases, including
idiopathic pulmonary fibrosis (IPF). We provide evidence that implicates chronic elevation of …

Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …