Autoantibodies are abnormal antibodies which are generated by pathogenic B cells when
targeting an individual's own tissue. Autoantibodies have been identified as a symbol of …

The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival
factor which supports autoreactive B cells and prevents their deletion. BAFF expression is …

The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
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An autoimmune disease is defined as a clinical syndrome resulted from an instigation of
both T cell and B cell or individually, in the absence of any present infection or any sort of …

Cytokines regulate a broad range of inflammatory processes that are implicated in the
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …

Despite major progress in the treatment of rheumatoid arthritis (RA), strong unmet medical
need remains, as only a minor proportion of patients reach sustained clinical remission. New …

The frequent observation of organized lymphoid structures that resemble secondary
lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as …

Fibroblast‐like synoviocytes (FLS) are resident mesenchymal cells of synovial joints that
have been recognized to play an increasingly important role in the pathogenesis of …

Rheumatoid arthritis is a complex systemic disease that ultimately leads to the progressive
destruction of articular and periarticular structures. Novel data indicate that the innate …

We examined expression of B cell–a ctivating f actor of the tumor necrosis factor (TNF) f
amily (BAFF) and a pr oliferation-i nducing l igand (APRIL) on chronic lymphocytic leukemia …