Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …

Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

Transcription factors are regulatory proteins that either activate or repress the transcription of
genes via binding to DNA regulatory sequences and regulating recruitment of transcriptional …

The Hippo pathway is a signalling cascade conserved from Drosophila melanogaster to
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

Tumors of the colorectum are amongst the most comof the new discoveries that are relevant
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …

Invasion and dissemination of well-differentiated carcinomas are often associated with loss
of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor cells at the …

Activation of Wnt signaling through β-catenin/TCF complexes is a key event in the
development of various tumors, in particular colorectal and liver tumors. Wnt signaling is …