There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis,
prognosis, and treatment of different tumor types. Described as a prognostic marker for many …

Tackling the growing incidence and prevalence of obesity urgently requires uncovering new
molecular pathways with therapeutic potential. The brain, and in particular the …

Lipotoxicity is a recognized pathological trigger and accelerator of nonalcoholic
steatohepatitis (NASH). However, the molecular basis of lipotoxicity-induced NASH remains …

Background Altered lipid metabolism is closely related to the occurrence and development
of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) is a member …

The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized,
while the precise molecular and cellular mechanisms involved are the focus of intense …

Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance,
and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on …

Breast cancer (BC) is the most common malignancy in women worldwide. While the main
systemic treatment option is anthracycline-containing chemotherapy, chemoresistance …

Endocannabinoid (eCB) signaling plays an important role in the central nervous system
(CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase …

The manifestation of intra-and inter-tumor heterogeneity hinders the development of
ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type …

The SF1 neurons of the ventromedial hypothalamus (VMH) are pivotal in governing body
weight and adiposity, particularly in response to a high-fat diet (HFD). Previous studies have …