The final steps of integrin activation: the end game
SJ Shattil, C Kim, MH Ginsberg - Nature reviews Molecular cell biology, 2010 - nature.com
Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …
[HTML][HTML] The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
Structural basis of integrin regulation and signaling
BH Luo, CV Carman, TA Springer - Annu. Rev. Immunol., 2007 - annualreviews.org
Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …
The effect of substrate stiffness on adult neural stem cell behavior
ND Leipzig, MS Shoichet - Biomaterials, 2009 - Elsevier
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal
and differentiation. In order to better understand the contribution of substrate stiffness to …
and differentiation. In order to better understand the contribution of substrate stiffness to …
[HTML][HTML] Immune cell migration in inflammation: present and future therapeutic targets
AD Luster, R Alon, UH von Andrian - Nature immunology, 2005 - nature.com
The burgeoning field of leukocyte trafficking has created new and exciting opportunities in
the clinic. Trafficking signals are being defined that finely control the movement of distinct …
the clinic. Trafficking signals are being defined that finely control the movement of distinct …
ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors
Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is
becoming a promising treatment option for hematological malignancies. However, T cell …
becoming a promising treatment option for hematological malignancies. However, T cell …
The insider's guide to leukocyte integrin signalling and function
N Hogg, I Patzak, F Willenbrock - Nature Reviews Immunology, 2011 - nature.com
The activation of leukocyte integrins through diverse receptors results in transformation of
the integrin from a bent, resting form to an extended conformation, which has at least two …
the integrin from a bent, resting form to an extended conformation, which has at least two …
The ins and outs of leukocyte integrin signaling
CL Abram, CA Lowell - Annual review of immunology, 2009 - annualreviews.org
Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …
activation in the immune system. These receptors signal bidirectionally through the plasma …
[HTML][HTML] Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces
The complete ectodomain of integrin α IIb β 3 reveals a bent, closed, low-affinity
conformation, the β knee, and a mechanism for linking cytoskeleton attachment to high …
conformation, the β knee, and a mechanism for linking cytoskeleton attachment to high …
Integrin structure, allostery, and bidirectional signaling
MA Arnaout, B Mahalingam… - Annu. Rev. Cell Dev. Biol., 2005 - annualreviews.org
Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …
matrix (ECM) interactions in metazoa that are critical in growth and development …