Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal
and differentiation. In order to better understand the contribution of substrate stiffness to …

The burgeoning field of leukocyte trafficking has created new and exciting opportunities in
the clinic. Trafficking signals are being defined that finely control the movement of distinct …

Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is
becoming a promising treatment option for hematological malignancies. However, T cell …

The activation of leukocyte integrins through diverse receptors results in transformation of
the integrin from a bent, resting form to an extended conformation, which has at least two …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

The complete ectodomain of integrin α IIb β 3 reveals a bent, closed, low-affinity
conformation, the β knee, and a mechanism for linking cytoskeleton attachment to high …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …