Simple Summary Gene inactivation is a powerful strategy to study the function of specific
proteins in the context of cellular physiology that can be applied for only non-essential …

The Boom syndrome helicase (BLM) unwinds a variety of DNA structures such as Guanine
(G)-quadruplex. Here we reveal a role of RNF111/Arkadia and its paralog ARKL1, as well as …

Biomedical research has been revolutionized by the introduction of many CRISPR-Cas
systems that induce programmable edits to nearly any gene in the human genome …

Targeted protein depletion using a conditional degron is a powerful method to probe the role
of proteins in living cells because of the speed with which depletion can be induced and its …

Recent developments in auxin-inducible degron (AID) technology have increased its
popularity for chemogenetic control of proteolysis. However, generation of human AID cell …

We designed a platform for monitoring the degradation of exogenous proteins in live cells.
We engineered a semi‐synthetic platform, which consists of Enhanced Green Fluorescent …

The discrimination of protein biological functions in different phases of the cell cycle is
limited by the lack of experimental approaches that do not require pre-treatment with …

The transcriptome dynamically changes via several transcriptional and post‐transcriptional
mechanisms. RNA‐binding proteins contribute to such mechanisms to regulate the cellular …

Nucleoli are large nuclear sub-compartments where vital processes, such as ribosome
assembly, take place. Technical obstacles still limit our understanding of the biological …

The auxin-inducible degron (AID) system is a versatile tool in cell biology and genetics,
enabling conditional protein regulation through auxin-induced degradation. Integrating …