Neuromodulation by the immune system: a focus on cytokines
Interactions between the immune system and the nervous system have been described
mostly in the context of diseases. More recent studies have begun to reveal how certain …
mostly in the context of diseases. More recent studies have begun to reveal how certain …
[HTML][HTML] The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes
The gastrointestinal tract is densely innervated by a complex network of neurons that
coordinate critical physiological functions. Here, we summarize recent studies investigating …
coordinate critical physiological functions. Here, we summarize recent studies investigating …
[HTML][HTML] Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain
M Matsuda, Y Huh, RR Ji - Journal of anesthesia, 2019 - Springer
Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
Pain and immunity: implications for host defence
Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …
Nociceptor sensory neuron–immune interactions in pain and inflammation
Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …
[HTML][HTML] Central nervous system targets: glial cell mechanisms in chronic pain
CR Donnelly, AS Andriessen, G Chen, K Wang… - …, 2020 - Elsevier
Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
[HTML][HTML] Mechanisms and therapeutic relevance of neuro-immune communication
Active research at the frontiers of immunology and neuroscience has identified multiple
points of interaction and communication between the immune system and the nervous …
points of interaction and communication between the immune system and the nervous …