Amyloid-ß (Aß) is best known as the misfolded peptide that is involved in the pathogenesis
of Alzheimer's disease (AD), and it is currently the primary therapeutic target in attempts to …

Background In resource limited settings acute febrile illnesses are often treated empirically
due to a lack of reliable, rapid point-of-care diagnostics. This contributes to the …

Neonatal meningitis is a devastating condition. Prognosis has not improved in decades,
despite the advent of improved antimicrobial therapy and heightened index of suspicion …

Kanamycin (KM) and amikacin (AK) are the key aminoglycoside drugs against tuberculosis
(TB) and resistance to them severely affects the options for treatment. Many explanations …

Apart from direct detection of the infecting organisms or biomarker of the pathogen itself,
surrogate host markers are also useful for sensitive and early diagnosis of pathogenic …

Tuberculous meningitis (TBM) is a serious complication of tuberculosis that affects the
central nervous system. Present methods to diagnose TBM are not suitable for early …

The prevalence of Parkinson's disease (PD) increases with age. Up to 50% of PD show
cognitive decline in terms of a mild cognitive impairment already in early stages that predict …

Streptococcus pneumoniae is responsible for diseases causing major global public health
problems, including meningitis, pneumonia and septicaemia. Despite recent advances in …

Differential diagnosis of bacterial and viral meningitis is an urgent problem of the modern
clinical medicine. Early and accurate detection of meningitis etiology largely determines the …

Background The detection of insulin autoantibodies (IAA) aids in the prediction of
autoimmune diabetes development. However, the long-standing, gold standard 125 I-insulin …