Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …

Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas
this may initiate disease in familial cases, onset in sporadic diseases may originate from a …

ER-mitochondrial contact sites (EMCSs) are important for mitochondrial function. Here, we
have identified a EMCS complex, comprising a family of uncharacterised mitochondrial outer …

Mitochondrial-endoplasmic reticulum contacts (MERC), a crucial mediator in subcellular
organelle communication, significantly influences the dynamics of tumor organelle. Despite …

HIV-associated neurological dysfunction is observed in more than half of the HIV-infected
population, even in the current antiretroviral era. The mechanisms by which HIV mediates …

Membrane contact sites (MCSs) are areas of close proximity between organelles, implicated
in transport of small molecules and in organelle biogenesis. Lipid transfer proteins at MCSs …

The excitation–contraction coupling (ECC) in skeletal muscle refers to the Ca2+-mediated
link between the membrane excitation and the mechanical contraction. The initiation and …

β‐barrel membrane proteins in the mitochondrial outer membrane are crucial for mediating
the metabolite exchange between the cytosol and the mitochondrial intermembrane space …

Eukaryotic cells are characterized by their exquisite compartmentalization resulting from a
cornucopia of membrane-bound organelles. Each of these compartments hosts a flurry of …