Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

CC motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an
integral chemotactic factor which recruits macrophages for the immune response. Together …

Uterine natural killer (uNK) cells are an immune subset located in the uterus. uNK cells have
distinct tissue-specific characteristics compared to their counterparts in peripheral blood and …

The presence of granulated lymphocytes in the human uterine mucosa, known as decidua
during pregnancy, or endometrium otherwise, was first noted in the nineteenth century, but it …

BACKGROUND With increasing significance of developmental programming effects
associated with placental dysfunction, more investigations are devoted to improving the …

Patients with recurrent pregnancy loss (RPL) account for approximately 1%-5% of women
aiming to achieve childbirth. Although studies have shown that RPL is associated with …

Single-cell RNA-sequencing (scRNA-seq) allows the characterization of cellular
composition and interactions in complex tissues. An essential prerequisite for scRNA-seq is …

Recurrent miscarriage (RM) is a chronic, heterogeneous autoimmune disease that has
serious social and personal consequences. No valid and reliable diagnostic markers or …

Pregnancy success requires constant dialogue between the mother and developing
conceptus. Such crosstalk is facilitated through complex interactions between maternal and …