Nutritional immunity is a form of innate immunity widespread in both vertebrates and
invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit …

The iron dependence of antibiotic-resistant microbes represents an Achilles' heel that can
be exploited broadly. The growing global problem of antibiotic resistance of microbial …

DIBI, a purpose-designed hydroxypyridinone-containing iron-chelating antimicrobial
polymer was studied for its anti-staphylococcal activities in vitro in comparison to …

There is a need to develop diagnostic and analytical tools that allow noninvasive monitoring
of bacterial growth and dissemination in vivo. For such cell-tracking studies to hold …

Vaccine discovery and development is mainly driven by studies on immunogenicity and
safety based on the appropriate animal models. In this review we will describe the …

Methicillin-resistant Staphylococcus aureus (MRSA) opportunistic infections are a major
health burden. Decolonization of hospitalized patients with mupirocin (MUP) has reduced …

Siderophores are a structurally diverse class of natural products common to most bacteria
and fungi as iron (III)-chelating ligands. Siderophores, including trihydroxamate …

Pathogenic microorganisms including bacteria and fungi have irreplaceable needs for iron
as critically needed for the activities of a wide array of essential enzymes that are vital for …

Staphylococcus aureus is a clinically important bacterial pathogen that has become resistant
to treatment with most routinely used antibiotics. Alternative strategies, such as vaccination …

Iron is a crucial secondary metabolite for bacterial proliferation, but its bioavailability under
infection conditions is limited by the low solubility of ferric ion and the host's ability to …