Neonatal infectious diseases: evaluation of neonatal sepsis

A Camacho-Gonzalez, PW Spearman… - Pediatric …, 2013 - pediatric.theclinics.com
Neonatal sepsis remains a feared and serious complication, especially among very low birth
weight (VLBW) preterm infants. Neonatal sepsis is divided into early-onset and late-onset …

Translational research and biomarkers in neonatal sepsis

JR Delanghe, MM Speeckaert - Clinica chimica acta, 2015 - Elsevier
As neonatal sepsis is a severe condition, there is a call for reliable biomarkers to
differentiate between infected and noninfected newborns. Although blood culture has been …

Immune intervention in sepsis

J Chen, H Wei - Frontiers in Pharmacology, 2021 - frontiersin.org
Sepsis is a host immune disorder induced by infection. It can lead to multiple organ
dysfunction syndrome (MODS), which has high morbidity and mortality. There has been …

Neonatal immune adaptation of the gut and its role during infections

E Tourneur, C Chassin - Journal of Immunology Research, 2013 - Wiley Online Library
The intestinal tract is engaged in a relationship with a dense and complex microbial
ecosystem, the microbiota. The establishment of this symbiosis is essential for host …

Genetics of bronchopulmonary dysplasia: An update

PM Lavoie, JH Rayment - Seminars in Perinatology, 2023 - Elsevier
Bronchopulmonary dysplasia (BPD) is a multi-factorial disease that results from a
combination of clinical factors, including lung immaturity, mechanical ventilation, oxidative …

The influence of the lectin pathway of complement activation on infections of the respiratory system

AS Świerzko, M Cedzyński - Frontiers in Immunology, 2020 - frontiersin.org
Lung diseases are among the leading causes of morbidity and mortality. Complement
activation may prevent a variety of respiratory infections, but on the other hand, could …

Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association …

ACM Dos Santos, BRC Dos Santos… - Infection, Genetics and …, 2021 - Elsevier
The Severe acute respiratory syndrome may be caused by coronavirus disease which has
resulted in a global pandemic. Polymorphisms in the population play a role in susceptibility …

Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis

T Sljivancanin Jakovljevic, J Martic, J Jacimovic… - World Journal of …, 2022 - Springer
Background The aim of this meta-analysis was to analyze all available data from studies
investigating associations between polymorphisms in genes responsible for innate immunity …

Restoration of MBL-deficiency: redefining the safety, efficacy and viability of MBL-substitution therapy

MP Keizer, D Wouters, LJ Schlapbach… - Molecular immunology, 2014 - Elsevier
MBL-deficiency is a commonly occurring deficiency of the innate immune system, affecting a
substantial part of the population and has been extensively studied. MBL appears to function …

Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women

S Jacobson, P Larsson, AM Åberg, G Johansson… - Journal of …, 2020 - Springer
Background Mannose-binding lectin (MBL) mediates the innate immune response either
through direct opsonisation of microorganisms or through activation of the complement …