The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …

Importance Overweight and obesity have been associated with adverse health effects.
Objective To systematically review evidence on benefits and harms of behavioral and …

The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous
semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term …

Importance The effect of continuing vs withdrawing treatment with semaglutide, a glucagon-
like peptide 1 receptor agonist, on weight loss maintenance in people with overweight or …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

Importance The effect of continued treatment with tirzepatide on maintaining initial weight
reduction is unknown. Objective To assess the effect of tirzepatide, with diet and physical …

Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a
gateway to ill health, and it has become one of the leading causes of disability and death …

Importance Five medications have been approved for the management of obesity, but data
on comparative effectiveness are limited. Objective To compare weight loss and adverse …

Importance Weight loss of 5% to 10% can improve type 2 diabetes and related
comorbidities. Few safe, effective weight-management drugs are currently available …

Cardiovascular disease risk factor control as primary prevention in patients with type 2
diabetes mellitus has changed substantially in the past few years. The purpose of this …