Mechanisms of cellular mRNA transcript homeostasis
S Berry, L Pelkmans - Trends in Cell Biology, 2022 - cell.com
For most genes, mRNA transcript abundance scales with cell size to ensure a constant
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …
Machine learning for small interfering RNAs: a concise review of recent developments
M Lee - Frontiers in Genetics, 2023 - frontiersin.org
The advent of machine learning and its subsequent integration into small interfering RNA
(siRNA) research heralds a new epoch in the field of RNA interference (RNAi). This review …
(siRNA) research heralds a new epoch in the field of RNA interference (RNAi). This review …
Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells
RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …
with cell size. Here, we study this in human cells by combining genome-wide perturbations …
Cellular state landscape and herpes simplex virus type 1 infection progression are connected
MK Pietilä, JJ Bachmann, J Ravantti… - Nature …, 2023 - nature.com
Prediction, prevention and treatment of virus infections require understanding of cell-to-cell
variability that leads to heterogenous disease outcomes, but the source of this heterogeneity …
variability that leads to heterogenous disease outcomes, but the source of this heterogeneity …
Learning consistent subcellular landmarks to quantify changes in multiplexed protein maps
Highly multiplexed imaging holds enormous promise for understanding how spatial context
shapes the activity of the genome and its products at multiple length scales. Here, we …
shapes the activity of the genome and its products at multiple length scales. Here, we …
All these screens that we've done: how functional genetic screens have informed our understanding of ribosome biogenesis
CM Harold - Bioscience Reports, 2023 - portlandpress.com
Ribosome biogenesis is the complex and essential process that ultimately leads to the
synthesis of cellular proteins. Understanding each step of this essential process is …
synthesis of cellular proteins. Understanding each step of this essential process is …
Nuclear RNA concentration coordinates RNA production with cell size in human cells
Unlike its DNA template, RNA abundance and synthesis rates increase with cell size, as part
of a mechanism of cellular RNA concentration homeostasis. Here, we study this scaling …
of a mechanism of cellular RNA concentration homeostasis. Here, we study this scaling …
A statistical framework for high-content phenotypic profiling using cellular feature distributions
YE Pearson, S Kremb, GL Butterfoss, X Xie… - Communications …, 2022 - nature.com
High-content screening (HCS) uses microscopy images to generate phenotypic profiles of
cell morphological data in high-dimensional feature space. While HCS provides detailed …
cell morphological data in high-dimensional feature space. While HCS provides detailed …
Defining innate immune checkpoints controlling Natural Killer cell recognition of melanoma cells
T Hofman - 2024 - archiv.ub.uni-heidelberg.de
Melanoma, though rare, stands as one of the most lethal forms of skin cancer. Immune
checkpoint inhibitors targeting inhibitory receptors on T cells represent an effective therapy …
checkpoint inhibitors targeting inhibitory receptors on T cells represent an effective therapy …
[图书][B] Not Just a Pipe's Dream: Plumbing the Contribution of Cell Diversity to Oesophageal Homeostasis
D Grommisch - 2023 - search.proquest.com
Epithelial barrier tissues like the skin, intestine, and oesophagus form a physical barrier that
protects our body from external threats. To accurately fulfil their function, epithelial barriers …
protects our body from external threats. To accurately fulfil their function, epithelial barriers …