Mechanisms of cellular mRNA transcript homeostasis

S Berry, L Pelkmans - Trends in Cell Biology, 2022 - cell.com
For most genes, mRNA transcript abundance scales with cell size to ensure a constant
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …

Machine learning for small interfering RNAs: a concise review of recent developments

M Lee - Frontiers in Genetics, 2023 - frontiersin.org
The advent of machine learning and its subsequent integration into small interfering RNA
(siRNA) research heralds a new epoch in the field of RNA interference (RNAi). This review …

Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells

S Berry, M Müller, A Rai, L Pelkmans - Cell Systems, 2022 - cell.com
RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …

Cellular state landscape and herpes simplex virus type 1 infection progression are connected

MK Pietilä, JJ Bachmann, J Ravantti… - Nature …, 2023 - nature.com
Prediction, prevention and treatment of virus infections require understanding of cell-to-cell
variability that leads to heterogenous disease outcomes, but the source of this heterogeneity …

Learning consistent subcellular landmarks to quantify changes in multiplexed protein maps

H Spitzer, S Berry, M Donoghoe, L Pelkmans… - Nature Methods, 2023 - nature.com
Highly multiplexed imaging holds enormous promise for understanding how spatial context
shapes the activity of the genome and its products at multiple length scales. Here, we …

All these screens that we've done: how functional genetic screens have informed our understanding of ribosome biogenesis

CM Harold - Bioscience Reports, 2023 - portlandpress.com
Ribosome biogenesis is the complex and essential process that ultimately leads to the
synthesis of cellular proteins. Understanding each step of this essential process is …

Nuclear RNA concentration coordinates RNA production with cell size in human cells

S Berry, M Müller, L Pelkmans - bioRxiv, 2021 - biorxiv.org
Unlike its DNA template, RNA abundance and synthesis rates increase with cell size, as part
of a mechanism of cellular RNA concentration homeostasis. Here, we study this scaling …

A statistical framework for high-content phenotypic profiling using cellular feature distributions

YE Pearson, S Kremb, GL Butterfoss, X Xie… - Communications …, 2022 - nature.com
High-content screening (HCS) uses microscopy images to generate phenotypic profiles of
cell morphological data in high-dimensional feature space. While HCS provides detailed …

Defining innate immune checkpoints controlling Natural Killer cell recognition of melanoma cells

T Hofman - 2024 - archiv.ub.uni-heidelberg.de
Melanoma, though rare, stands as one of the most lethal forms of skin cancer. Immune
checkpoint inhibitors targeting inhibitory receptors on T cells represent an effective therapy …

[图书][B] Not Just a Pipe's Dream: Plumbing the Contribution of Cell Diversity to Oesophageal Homeostasis

D Grommisch - 2023 - search.proquest.com
Epithelial barrier tissues like the skin, intestine, and oesophagus form a physical barrier that
protects our body from external threats. To accurately fulfil their function, epithelial barriers …