Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals

F Abbaszadeh, S Fakhri, H Khan - Pharmacological research, 2020 - Elsevier
Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

Natural phytochemicals as novel therapeutic strategies to prevent and treat Parkinson's disease: current knowledge and future perspectives

R Balakrishnan, S Azam, DY Cho… - Oxidative Medicine …, 2021 - Wiley Online Library
Parkinson's disease (PD) is the second‐most common neurodegenerative chronic disease
affecting both cognitive performance and motor functions in aged people. Yet despite the …

Protective effects of flavonoids against Alzheimer's disease: pathological hypothesis, potential targets, and structure–activity relationship

J Li, M Sun, X Cui, C Li - International Journal of Molecular Sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease with high morbidity and mortality,
for which there is no available cure. Currently, it is generally believed that AD is a disease …

[HTML][HTML] An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches

M Talebi, M Talebi, T Farkhondeh… - Biomedicine & …, 2021 - Elsevier
Neurological diseases are responsible for a large number of morbidities and mortalities in
the world. Flavonoids are phytochemicals that possess various health-promoting impacts …

Neuroprotective potential of chrysin: Mechanistic insights and therapeutic potential for neurological disorders

A Mishra, PS Mishra, R Bandopadhyay, N Khurana… - Molecules, 2021 - mdpi.com
Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including
anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of …

[HTML][HTML] Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms

S Gao, N Siddiqui, I Etim, T Du, Y Zhang… - Biomedicine & …, 2021 - Elsevier
Chrysin is a promising naturally occurring flavonoid mainly found in honey and propolis.
Although chrysin's biological activities have been demonstrated and the mechanism of …

Therapeutic nanotechnologies for Alzheimer's disease: A critical analysis of recent trends and findings

P Delbreil, JM Rabanel, X Banquy… - Advanced Drug Delivery …, 2022 - Elsevier
Alzheimer's Disease (AD) is an irreversible neurodegenerative disease for which no
modifying therapies are presently available. Besides the identification of pathological …

Lipid shell lipid nanocapsules as smart generation lipid nanocarriers

N Dabholkar, T Waghule, VK Rapalli, S Gorantla… - Journal of Molecular …, 2021 - Elsevier
Lipid nanocapsules (LNCs) are lipid-based nanocarriers that have found application as drug
delivery systems, in diagnostics, and theranostics. They are biocompatible and able to …

Core–shell type lipidic and polymeric nanocapsules: the transformative multifaceted delivery systems

A Mehandole, N Walke, S Mahajan, M Aalhate… - AAPS …, 2023 - Springer
Amongst the several nano-drug delivery systems, lipid or polymer-based core–shell
nanocapsules (NCs) have garnered much attention of researchers owing to its …

Natural polyphenol: Their pathogenesis-targeting therapeutic potential in Alzheimer's disease

C Niu, M Dong, Y Niu - European journal of medicinal chemistry, 2024 - Elsevier
Alzheimer's disease (AD) is a detrimental neurodegenerative disease affecting the elderly.
Clinically, it is characterized by progressive memory decline and subsequent loss of broader …