MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …

Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …

In multiple sclerosis (MS), iron accumulates inside activated microglia/macrophages at
edges of some chronic demyelinated lesions, forming rims. In susceptibility-based magnetic …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in
multiple sclerosis (MS) and have implications for non-relapsing biological progression. In …

BACKGROUND AND PURPOSE: Previous studies have suggested that the central vein sign
and iron rims are specific features of MS lesions. Using 3T SWI, we aimed to compare the …

Introduction In multiple sclerosis (MS), paramagnetic rim lesions (PRLs) on MRI identify a
subset of chronic active lesions (CALs), which have been linked through clinical and …

Quantitative susceptibility mapping (QSM) is an MR technique that depicts and quantifies
magnetic susceptibility sources. Mapping iron, the dominant susceptibility source in the …

Measuring iron content has practical clinical indications in the study of diseases such as
Parkinson's disease, Huntington's disease, ferritinopathies and multiple sclerosis as well as …

Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis
(MS), for investigating the disease pathophysiology, and for discriminating MS from other …