Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies

D Grinsell, CP Keating - BioMed research international, 2014 - Wiley Online Library
Unlike other tissues in the body, peripheral nerve regeneration is slow and usually
incomplete. Less than half of patients who undergo nerve repair after injury regain good to …

Scaffolds for peripheral nerve repair and reconstruction

S Yi, L Xu, X Gu - Experimental neurology, 2019 - Elsevier
Trauma-associated peripheral nerve defect is a widespread clinical problem. Autologous
nerve grafting, the current gold standard technique for the treatment of peripheral nerve …

Mitochondrial respiration as a target for neuroprotection and cognitive enhancement

F Gonzalez-Lima, BR Barksdale, JC Rojas - Biochemical pharmacology, 2014 - Elsevier
This paper focuses on brain mitochondrial respiration as a therapeutic target for
neuroprotection and cognitive enhancement. We propose that improving brain mitochondrial …

[HTML][HTML] HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI)

S Canavero - Surgical Neurology International, 2013 - ncbi.nlm.nih.gov
In 1970, the first cephalosomatic linkage was achieved in the monkey. However, the
technology did not exist for reconnecting the spinal cord, and this line of research was no …

Polyethylene glycol (PEG) and other bioactive solutions with neurorrhaphy for rapid and dramatic repair of peripheral nerve lesions by PEG-fusion

CL Ghergherehchi, M Mikesh, DR Sengelaub… - Journal of neuroscience …, 2019 - Elsevier
Background Nervous system injuries in mammals often involve transection or segmental
loss of peripheral nerves. Such injuries result in functional (behavioral) deficits poorly …

Typical and atypical properties of peripheral nerve allografts enable novel strategies to repair segmental-loss injuries

GD Bittner, JS Bushman, CL Ghergherehchi… - Journal of …, 2022 - Springer
We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve
segment are the most common type of traumatic injury to nervous systems. Segmental-loss …

The curious ability of polyethylene glycol fusion technologies to restore lost behaviors after nerve severance

GD Bittner, DR Sengelaub, RC Trevino… - Journal of …, 2016 - Wiley Online Library
Traumatic injuries to PNS and CNS axons are not uncommon. Restoration of lost behaviors
following severance of mammalian peripheral nerve axons (PNAs) relies on regeneration by …

Polyethylene glycol‐fused allografts produce rapid behavioral recovery after ablation of sciatic nerve segments

DC Riley, GD Bittner, M Mikesh… - Journal of …, 2015 - Wiley Online Library
Restoration of neuronal functions by outgrowths regenerating at∼ 1 mm/day from the
proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all …

[HTML][HTML] Enhanced hydrogen peroxide generation accompanies the beneficial bioenergetic effects of methylene blue in isolated brain mitochondria

L Tretter, G Horvath, A Hölgyesi, F Essek… - Free radical biology and …, 2014 - Elsevier
The redox dye methylene blue (MB) is proven to have beneficial effects in various models of
neurodegenerative diseases. Here we investigated the effects of MB (100 nM, 300 nM, and …

Gold nanoparticle and polyethylene glycol in neural regeneration in the treatment of neurodegenerative diseases

T Aghaie, MH Jazayeri, M Manian… - Journal of Cellular …, 2019 - Wiley Online Library
Gold nanoparticles (GNs) have unique characteristics, for example, stability,
biocompatibility, small dimensions, and low toxicity. Several clinical applications have been …