Unlike other tissues in the body, peripheral nerve regeneration is slow and usually
incomplete. Less than half of patients who undergo nerve repair after injury regain good to …

Trauma-associated peripheral nerve defect is a widespread clinical problem. Autologous
nerve grafting, the current gold standard technique for the treatment of peripheral nerve …

This paper focuses on brain mitochondrial respiration as a therapeutic target for
neuroprotection and cognitive enhancement. We propose that improving brain mitochondrial …

In 1970, the first cephalosomatic linkage was achieved in the monkey. However, the
technology did not exist for reconnecting the spinal cord, and this line of research was no …

Background Nervous system injuries in mammals often involve transection or segmental
loss of peripheral nerves. Such injuries result in functional (behavioral) deficits poorly …

We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve
segment are the most common type of traumatic injury to nervous systems. Segmental-loss …

Traumatic injuries to PNS and CNS axons are not uncommon. Restoration of lost behaviors
following severance of mammalian peripheral nerve axons (PNAs) relies on regeneration by …

Restoration of neuronal functions by outgrowths regenerating at∼ 1 mm/day from the
proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all …

The redox dye methylene blue (MB) is proven to have beneficial effects in various models of
neurodegenerative diseases. Here we investigated the effects of MB (100 nM, 300 nM, and …

Gold nanoparticles (GNs) have unique characteristics, for example, stability,
biocompatibility, small dimensions, and low toxicity. Several clinical applications have been …