New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

[HTML][HTML] The neuropsychopharmacology of cannabis: A review of human imaging studies

MAP Bloomfield, C Hindocha, SF Green… - Pharmacology & …, 2019 - Elsevier
The laws governing cannabis are evolving worldwide and associated with changing
patterns of use. The main psychoactive drug in cannabis is Δ 9-tetrahydrocannabinol (THC) …

Molecular pharmacology of phytocannabinoids

SE Turner, CM Williams, L Iversen… - … : unraveling the complex …, 2017 - Springer
Cannabis sativa has been used for recreational, therapeutic and other uses for thousands of
years. The plant contains more than 120 C 21 terpenophenolic constituents named …

[HTML][HTML] Cannabinoids as therapeutic agents in cancer: current status and future implications

B Chakravarti, J Ravi, RK Ganju - Oncotarget, 2014 - ncbi.nlm.nih.gov
The pharmacological importance of cannabinoids has been in study for several years.
Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant,(b) …

Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity?

WE Fantegrossi, JH Moran, A Radominska-Pandya… - Life sciences, 2014 - Elsevier
K2 or Spice products are emerging drugs of abuse that contain synthetic cannabinoids
(SCBs). Although assumed by many teens and first time drug users to be a “safe” and “legal” …

Hexahydrocannabinol pharmacology, toxicology, and analysis: the first evidence for a recent new psychoactive substance

S Graziano, MR Varì, S Pichini… - Current …, 2023 - benthamdirect.com
Background: During the last two years, hexahydrocannabinol (HHC), the hydrogenated
derivative of tetrahydrocannabinol has been freely sold by internet websites as a “legal” …

Miswiring the brain: Δ9‐tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin‐2 degradation pathway

G Tortoriello, CV Morris, A Alpar, J Fuzik… - The EMBO …, 2014 - embopress.org
Children exposed in utero to cannabis present permanent neurobehavioral and cognitive
impairments. Psychoactive constituents from Cannabis spp., particularly Δ9 …

Current evidence of cannabinoid‐based analgesia obtained in preclinical and human experimental settings

J Lötsch, I Weyer‐Menkhoff… - European journal of pain, 2018 - Wiley Online Library
Cannabinoids have a long record of recreational and medical use and become increasingly
approved for pain therapy. This development is based on preclinical and human …

UK Medical Cannabis registry: an analysis of clinical outcomes of medicinal cannabis therapy for chronic pain conditions

M Harris, S Erridge, M Ergisi, D Nimalan… - Expert review of …, 2022 - Taylor & Francis
Objectives To explore pain-specific, general health-related quality of life (HRQoL), and
safety outcomes of chronic pain patients prescribed cannabis-based medicinal products …

Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer's disease

M Coles, GZ Steiner-Lim, T Karl - Frontiers in Neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by
declining cognition and behavioral impairment, and hallmarked by extracellular amyloid-β …