Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …

The rhomboid proteases were first discovered as regulators of Drosophila EGF receptor
signaling; soon after, it was recognized that they represented the founder members of a …

Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-
secretase recognizes its substrate remains unknown. Here we report the cryo-electron …

Rhomboid proteases hydrolyze substrate helices within the lipid bilayer to release soluble
domains from the membrane. Here, we investigate the mechanism of activity regulation for …

CAAX proteins have essential roles in multiple signalling pathways, controlling processes
such as proliferation, differentiation and carcinogenesis. The∼ 120 mammalian CAAX …

Enzymatic cleavage of transmembrane anchors to release proteins from the membrane
controls diverse signaling pathways and is implicated in more than a dozen diseases. How …

iRhom proteins are catalytically inactive relatives of rhomboid intramembrane proteases.
There is a rapidly growing body of evidence that these pseudoenzymes have a central …

Rhomboid proteases reside within cellular membranes, but the advantage of this unusual
environment is unclear. We discovered membrane immersion allows substrates to be …

The mechanisms of intramembrane proteases are incompletely understood due to the lack
of structural data on substrate complexes. To gain insight into substrate binding by rhomboid …

The rhomboid superfamily of transmembrane (TM) proteins includes intramembrane serine
proteases and several classes of pseudoprotease. Rhomboid-like proteins occur widely …