Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

Simple Summary Ovarian cancer is a highly lethal female malignancy with high rates of
advanced stage and recurrent disease. Ovarian cancer is characterized as poorly …

Nanoparticles for the detection and treatment of cancer have suffered from limited clinical
translation. A key problem has been the lack of understanding of the mechanisms of …

The physical properties of nanomaterials—such as size, structure, shape, charge,
mechanical strength and hydrophobicity—can directly or indirectly influence immune cell …

Immunotherapy has revolutionized cancer treatment, dramatically improving survival rates of
melanoma and lung cancer patients. Nevertheless, immunotherapy is almost ineffective …

Hypoxia is the major influence factor in physiological and pathological courses which are
mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions …

The critical role of tumor microenvironment (TME) in tumor initiation and development has
been well-recognized after more than a century of studies. Numerous therapeutic …

Imaging and tracking macrophage behaviors in vivo are essential to reveal its biological
function and fate in various diseases. Small molecular probes suffer from poor macrophage …

Bio–nanoscience research encompasses studies on the interactions of nanomaterials with
biological structures or what is commonly referred to as the biointerface. Fundamental …

The innate immune system plays a key role as the first line of defense in various human
diseases including cancer, cardiovascular and inflammatory diseases. In contrast to tissue …