Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

This Review explores the interplay between T cell activation and cell metabolism and
highlights how metabolites serve two pivotal functions in shaping the immune response …

Alzheimer's disease is pathologically characterized by abnormal accumulation of amyloid-
beta plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, and …

Melatonin, the hormone of the pineal gland, possesses a range of physiological functions,
and recently, its anticancer effect has become more apparent. A more thorough …

The ability to maintain cellular metabolic homeostasis is critical to life, in which mTOR plays
an important role. This kinase integrates upstream nutrient signals and performs essential …

The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that
regulates multiple processes, including gene transcription, protein synthesis, ribosome …

Rotenone (ROT) inhibits mitochondrial complex I, leading to reactive oxygen species
formation, which causes neurodegeneration and alpha-synuclein (α-syn) aggregation and …

Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease associated with the
central nervous system (CNS). Autoimmunity is caused by an abnormal immune response to …

In humans, age-associated degrading changes, widely observed in molecular and cellular
processes underly the time-dependent decline in spatial navigation, time perception …

Human cytomegalovirus (HCMV) utilizes peripheral blood monocytes as a means to
systemically disseminate throughout the host. Following viral entry, HCMV stimulates non …