The chemistry and biology of organic guanidine derivatives

RGS Berlinck, AE Trindade-Silva… - Natural Product …, 2012 - pubs.rsc.org
Covering: 2010 and 2011. Previous review: Nat. Prod. Rep., 2010, 27, 1871 The chemistry
and biology of organic natural guanidines are reviewed, including the isolation, structure …

The cyanamide moiety, synthesis and reactivity

MH Larraufie, G Maestri, M Malacria, C Ollivier… - …, 2012 - thieme-connect.com
The cyanamide moiety provides many opportunities as a building block for the synthesis of
nitrogen-containing heterocycles. This review discusses the reported methods for the …

Synthesis of 7-membered heterocyclic compounds and their biological activity

R Rana, A Ansari - Journal of Physics: Conference Series, 2023 - iopscience.iop.org
Heterocyclic compounds are an important class of organic compound. Owing to their
usefulness in synthetic processes, numerous heterocyclic compounds are currently known …

Capture–Collapse Heterocyclization: 1, 3-Diazepanes by C–N Reductive Elimination from Rhodacyclopentanones

NG McCreanor, S Stanton… - Journal of the American …, 2016 - ACS Publications
Rhodacyclopentanones derived from carbonylative C–C activation of cyclopropyl ureas can
be “captured” by pendant nucleophiles prior to “collapse” to 1, 3-diazepanes. The choice of …

Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA

S Zhou, KD Rynearson, K Ding, ND Brunn… - Bioorganic & medicinal …, 2013 - Elsevier
The highly conserved internal ribosome entry site (IRES) of hepatitis C virus (HCV) regulates
translation of the viral RNA genome and is essential for the expression of HCV proteins in …

Synthetic approaches to heterocyclic guanidines with biological activity: An update

SG Zarate, AG Santana, A Bastida… - Current Organic …, 2014 - ingentaconnect.com
The guanidine functional group is an important structural motif in synthesis with a wide
range of interesting properties. Guanidines are frequently found in bioactive compounds; …

Enantioselective reaction of N-cyano imines: decarboxylative Mannich-type reaction with malonic acid half thioesters

Y Oyamada, K Inaba, T Sasamori… - Chemical …, 2022 - pubs.rsc.org
The enantioselective reaction of imines bearing a cyano group as an activating group with
malonic acid half thioesters gave chiral cyanamide derivatives with high enantioselectivity …

Twin displacive phase transitions in amino acid quasiracemates

CH Görbitz, P Karen - The Journal of Physical Chemistry B, 2015 - ACS Publications
Three quasiracemates, l-norleucine: d-methionine, l-norvaline: d-norleucine, and l-
norvaline: d-methionine, were crystallized to see how they differ from regular racemates in …

One-Pot Acid-Promoted Synthesis of 6-Aminopyrazolopyrimidines from 1H-Pyrazol-5-yl-N,N-dimethylformamidines or 5-Amino-1H-pyrazole-4-carbaldehydes with …

CC Tseng, SE Tsai, SM Li, FF Wong - The Journal of Organic …, 2019 - ACS Publications
A convenient and efficient one-pot acid-promoted synthesis of 6-aminopyrazolo [3, 4-d]
pyrimidine has been developed by treatment of 1 H-pyrazol-5-yl-N, N-dimethylformamidines …

Seven-membered rings

JH Ryan, JL Green, C Hyland, JA Smith… - Progress in Heterocyclic …, 2011 - Elsevier
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