Adequate intake of the essential trace element and micronutrient selenium is thought to be
beneficial for maintaining human health. Selenium may modulate a broad spectrum of key …

The human intestinal Caco-2 cell line has been extensively used over the last twenty years
as a model of the intestinal barrier. The parental cell line, originally obtained from a human …

The mucus layer covering the gastrointestinal mucosa is considered the first line of defense
against aggressions arising from the luminal content. It is mainly composed of high …

We subjected cells collected using an in vivo invasion assay to cDNA microarray analysis to
identify the gene expression profile of invasive carcinoma cells in primary mammary tumors …

The class II Histone deacetylase (HDAC), HDAC4, is expressed in a tissue-specific manner,
and it represses differentiation of specific cell types. We demonstrate here that HDAC4 is …

Lysyl oxidase (LOX) is an extracellular matrix (ECM) enzyme that catalyzes the cross‐linking
of collagens or elastin in the extracellular compartment, thereby regulating the tensile …

Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic
choices in inflammatory bowel diseases (IBD), however, with limited remission and often …

Fluorouracil (5-FU) is the most common chemotherapeutic agent used in the treatment of
colorectal cancer, yet objective response rates are low. Recently, camptothecin (CPT) has …

Background & Aims: To define the genetic reprogramming that drives intestinal epithelial cell
maturation along the crypt-villus axis, enterocytes were sequentially isolated from the villus …

Copper amine oxidases (CAOs) are a class of enzymes that contain Cu 2+ and a tyrosine-
derived quinone cofactor, catalyze the conversion of a primary amine functional group to an …