Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …

DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …

Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …