Chalcone derivatives: role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

[HTML][HTML] Combined photodynamic and photothermal therapy and immunotherapy for cancer treatment: a review

C Kong, X Chen - International journal of nanomedicine, 2022 - ncbi.nlm.nih.gov
Photoactivation therapy based on photodynamic therapy (PDT) and photothermal therapy
(PTT) has been identified as a tumour ablation modality for numerous cancer indications …

Recent discoveries of anticancer flavonoids

D Raffa, B Maggio, MV Raimondi, F Plescia… - European journal of …, 2017 - Elsevier
In this review we report the recent advances in anticancer activity of the family of natural
occurring flavonoids, covering the time span of the last five years. The bibliographic data will …

Recent developments in biological activities of chalcones: A mini review

P Singh, A Anand, V Kumar - European journal of medicinal chemistry, 2014 - Elsevier
Chalcones represent key structural motif in the plethora of biologically active molecules
including synthetic and natural products. Synthetic manipulations of chalcones or their …

Chalcones: Synthetic chemistry follows where nature leads

HA Jasim, L Nahar, MA Jasim, SA Moore, KJ Ritchie… - Biomolecules, 2021 - mdpi.com
Chalcones belong to the flavonoid class of phenolic compounds. They form one of the
largest groups of bioactive natural products. The potential anticancer, anti-inflammatory …

Natural products and synthetic analogs as a source of antitumor drugs

J Sharifi-Rad, A Ozleyen, T Boyunegmez Tumer… - Biomolecules, 2019 - mdpi.com
Cancer is a heterogeneous disease and one of the major issues of health concern,
especially for the public health system globally. Nature is a source of anticancer drugs with …

Synthesis of chalcones with anticancer activities

S Syam, SI Abdelwahab, MA Al-Mamary, S Mohan - Molecules, 2012 - mdpi.com
Several chalcones were synthesized and their in vitro cytotoxicity against various human cell
lines, including human breast adenocarcinoma cell line MCF-7, human lung …

[HTML][HTML] Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest

W Chen, Y Liu, M Li, J Mao, L Zhang, R Huang… - Journal of …, 2015 - Elsevier
Abstracts Pine needle oil from crude extract of pine needles has been used as an anti-
cancer agent in Traditional Chinese Medicine. The α-pinene is a natural compound isolated …

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy

J Wang, Q Qi, W Zhou, Z Feng, B Huang, A Chen… - Autophagy, 2018 - Taylor & Francis
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various
types of cancer. The mechanism of action, however, remains unclear. Here, we evaluated …

4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways

P Duan, C Hu, C Quan, T Yu, W Zhou, M Yuan, Y Shi… - Toxicology, 2016 - Elsevier
Abstract The xenoestrogen 4-nonylphenol (NP) induces reproductive dysfunction of male
rats, but the fundamental mechanism of this phenomenon is largely unexplored. Sertoli cells …