Pharmacology of adenosine receptors: the state of the art

PA Borea, S Gessi, S Merighi… - Physiological …, 2018 - journals.physiology.org
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Immunity, inflammation and cancer: a leading role for adenosine

L Antonioli, C Blandizzi, P Pacher, G Haskó - Nature Reviews Cancer, 2013 - nature.com
Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …

CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression

D Jin, J Fan, L Wang, LF Thompson, A Liu, BJ Daniel… - Cancer research, 2010 - AACR
CD73, originally defined as a lymphocyte differentiation antigen, is thought to function as a
cosignaling molecule on T lymphocytes and an adhesion molecule that is required for …

Personalized immunotherapy against several neuronal and brain tumors

S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Purinergic signalling and cancer

G Burnstock, F Di Virgilio - Purinergic signalling, 2013 - Springer
Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

KA Jacobson, S Merighi, K Varani… - Medicinal research …, 2018 - Wiley Online Library
The A3 adenosine receptor (A3AR) subtype is a novel, promising therapeutic target for
inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver …

HIF‐dependent induction of adenosine A2B receptor in hypoxia

T Kong, KA Westerman, M Faigle… - The FASEB …, 2006 - Wiley Online Library
Adenosine has been widely associated with hypoxia of many origins, including those
associated with inflammation and tumorogenesis. A number of recent studies have …

Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells

DW Hoskin, JS Mader, SJ Furlong… - International …, 2008 - spandidos-publications.com
The resistance of many human cancers to immune-based therapies, including adoptive
immunotherapy and the administration of therapeutic cancer vaccines, has been attributed …

[HTML][HTML] Adenosine receptors and cancer

S Gessi, S Merighi, V Sacchetto, C Simioni… - Biochimica et Biophysica …, 2011 - Elsevier
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A1, A2A, A2B and …

P2 receptors and cancer

N White, G Burnstock - Trends in pharmacological sciences, 2006 - cell.com
Purinergic signalling has been implicated in many biological processes, and ATP and other
extracellular nucleotides might have therapeutic potential in the treatment of cancer by …