Statins: a viable candidate for host-directed therapy against infectious diseases
Statins were first identified over 40 years ago as lipid-lowering drugs and have been
remarkably effective in treating cardiovascular diseases. As research advanced, the …
remarkably effective in treating cardiovascular diseases. As research advanced, the …
Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi
E Bencosme-Cuevas, TK Kim, TT Nguyen… - Frontiers in Cellular …, 2023 - frontiersin.org
Tick serine protease inhibitors (serpins) play crucial roles in tick feeding and pathogen
transmission. We demonstrate that Ixodes scapularis (Ixs) nymph tick saliva serpin (S) 41 …
transmission. We demonstrate that Ixodes scapularis (Ixs) nymph tick saliva serpin (S) 41 …
Current and emerging approaches for eliminating Borrelia burgdorferi and alleviating persistent Lyme disease symptoms
K Zafar, OC Azuama, N Parveen - Frontiers in Microbiology, 2024 - frontiersin.org
Lyme disease is the most prevalent tick-borne infection caused by Borrelia burgdorferi
bacteria in North America. Other Borrelia species are predominately the cause of this …
bacteria in North America. Other Borrelia species are predominately the cause of this …
A tick saliva serpin, IxsS17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent
TT Nguyen, TH Kim, E Bencosme-Cuevas… - PLoS …, 2024 - journals.plos.org
Lyme disease (LD) caused by Borrelia burgdorferi is among the most important human
vector borne diseases for which there is no effective prevention method. Identification of tick …
vector borne diseases for which there is no effective prevention method. Identification of tick …
Metabolic modeling predicts unique drug targets in Borrelia burgdorferi
PJ Gwynne, KLK Stocks, ES Karozichian, A Pandit… - Msystems, 2023 - Am Soc Microbiol
ABSTRACT The Lyme disease bacterium Borrelia burgdorferi is extremely host dependent,
with a small genome and correspondingly limited metabolism. As such, it is an excellent …
with a small genome and correspondingly limited metabolism. As such, it is an excellent …
Cholesterol contributes to risk, severity, and machine learning-driven diagnosis of Lyme disease
IS Forrest, AJ O'Neal, JHF Pedra… - Clinical Infectious …, 2023 - academic.oup.com
Background Lyme disease is the most prevalent vector-borne disease in the US, yet its host
factors are poorly understood and diagnostic tests are limited. We evaluated patients in a …
factors are poorly understood and diagnostic tests are limited. We evaluated patients in a …
Short-chain fatty acids alter metabolic and virulence attributes of Borrelia burgdorferi
Borrelia burgdorferi responds to a variety of host-derived factors and appropriately alters its
gene expression for adaptation under different host-specific conditions. We previously …
gene expression for adaptation under different host-specific conditions. We previously …
Comparison of minimum inhibitory concentration (MIC) value of statin drugs: a systematic review
Background: Microbial infection and its resistance to clinically approved drugs create a huge
threat to human health. Emerging reports have indicated the potential of statin drugs in the …
threat to human health. Emerging reports have indicated the potential of statin drugs in the …
Cellular and transcriptome signatures unveiled by single-cell RNA-Seq following ex vivo infection of murine splenocytes with Borrelia burgdorferi
V Kumaresan, TMM Ingle, N Kilgore, G Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Lyme disease, the most common tick-borne infectious disease in the US, is
caused by a spirochetal pathogen Borrelia burgdorferi (Bb). Distinct host responses are …
caused by a spirochetal pathogen Borrelia burgdorferi (Bb). Distinct host responses are …
Association between statin use and clinical course, microbiologic characteristics, and long-term outcome of early Lyme borreliosis. A post hoc analysis of prospective …
D Stupica, FF Bajrović, R Blagus, T Cerar Kišek… - Plos one, 2021 - journals.plos.org
Background Statins were shown to inhibit borrelial growth in vitro and promote clearance of
spirochetes in a murine model of Lyme borreliosis (LB). We investigated the impact of statin …
spirochetes in a murine model of Lyme borreliosis (LB). We investigated the impact of statin …