The β-sheet–rich amyloid core is the defining feature of protein aggregates associated with
neurodegenerative disorders. Recent investigations have revealed that there exist multiple …

Simple Summary Tau is an important protein for maintaining the shape and normal function
of nerve cells. There are many diseases that are identified by changes in this protein, yet …

Pathological tau aggregates cause cognitive decline in neurodegenerative tauopathies,
including Alzheimer's disease (AD). These aggregates are prevalent within intracellular …

Alzheimer's disease is the most prevalent neurodegenerative disease affecting older adults.
Primary features of Alzheimer's disease include extracellular aggregation of amyloid-β …

Aging, tau pathology, and chronic inflammation in the brain play crucial roles in synaptic
loss, neurodegeneration, and cognitive decline in tauopathies, including Alzheimer's …

Introduction Tau has commanded much attention as a potential therapeutic target in
neurodegenerative diseases. Tau pathology is a hallmark of primary tauopathies, such as …

The misfolding and aggregation of the tau protein into neurofibrillary tangles constitutes a
central feature of tauopathies. Traumatic brain injury (TBI) has emerged as a potential risk …

Tau, one of the most abundant microtubule‐associated protein in neurons plays a role in
regulating microtubule dynamics in axons, as well as shaping the overall morphology of the …

Tau protein misfolding and aggregation are pathological hallmarks of Alzheimer's disease
and over twenty neurodegenerative disorders. However, the molecular mechanisms of tau …

Tau oligomers have been shown to be the main toxic tau species in several
neurodegenerative disorders. To study tau oligomers, we have developed reagents and …