[HTML][HTML] MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets

S Liu, M Fan, Q Zheng, S Hao, L Yang, Q Xia… - Biomedicine & …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease, with cognitive
decline as the primary clinical feature. According to epidemiological statistics, 50 million …

The complexity of Alzheimer's disease: an evolving puzzle

C Ferrari, S Sorbi - Physiological reviews, 2021 - journals.physiology.org
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …

[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …

Epigenetics of Alzheimer's disease

M Nikolac Perkovic, A Videtic Paska, M Konjevod… - Biomolecules, 2021 - mdpi.com
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment

L Cheng, JD Doecke, RA Sharples, VL Villemagne… - Molecular …, 2015 - nature.com
There is no consensus for a blood-based test for the early diagnosis of Alzheimer's disease
(AD). Expression profiling of small non-coding RNA's, microRNA (miRNA), has revealed …

Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease

L Su, R Li, Z Zhang, J Liu, J Du, H Wei - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
decreased memory and cognitive functions. Exosomes carry a variety of important …

Noncoding RNAs in Alzheimer's disease

ML Idda, R Munk, K Abdelmohsen… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause
of dementia among the elderly worldwide. Despite intense efforts to develop drugs for …

Role of miRNAs in neurodegeneration: From disease cause to tools of biomarker discovery and therapeutics

B Roy, E Lee, T Li, M Rampersaud - Genes, 2022 - mdpi.com
Neurodegenerative diseases originate from neuronal loss in the central nervous system
(CNS). These debilitating diseases progress with age and have become common due to an …

[HTML][HTML] Biomarkers for the early detection and progression of Alzheimer's disease

SE Counts, MD Ikonomovic, N Mercado, IE Vega… - …, 2017 - Elsevier
The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …

Cerebrospinal fluid biomarkers of Alzheimer's disease: current evidence and future perspectives

DA McGrowder, F Miller, K Vaz, C Nwokocha… - Brain sciences, 2021 - mdpi.com
Alzheimer's disease is a progressive, clinically heterogeneous, and particularly complex
neurodegenerative disease characterized by a decline in cognition. Over the last two …