Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Endothelial to mesenchymal transition in health and disease

Y Xu, JC Kovacic - Annual Review of Physiology, 2023 - annualreviews.org
The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …

TGF-β-induced endothelial to mesenchymal transition in disease and tissue engineering

J Ma, G Sanchez-Duffhues, MJ Goumans… - Frontiers in cell and …, 2020 - frontiersin.org
Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Associations between systemic immune-inflammation index and abdominal aortic calcification: results of a nationwide survey

R Xie, X Liu, H Wu, M Liu, Y Zhang - Nutrition, Metabolism and …, 2023 - Elsevier
Abstract Background and aim The Systemic Immune-Inflammation Index (SII) is a novel
index of inflammation assessment that appears to be superior to the common single blood …

Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease

Y Yoshimatsu, T Watabe - Inflammation and Regeneration, 2022 - Springer
Abstract Endothelial–mesenchymal transition (EndoMT), a cellular differentiation process in
which endothelial cells (ECs) lose their properties and differentiate into mesenchymal cells …

TNF‐α enhances TGF‐β‐induced endothelial‐to‐mesenchymal transition via TGF‐β signal augmentation

Y Yoshimatsu, I Wakabayashi, S Kimuro… - Cancer …, 2020 - Wiley Online Library
The tumor microenvironment (TME) consists of various components including cancer cells,
tumor vessels, cancer‐associated fibroblasts (CAFs), and inflammatory cells. These …

The role of bone morphogenetic protein signaling in vascular calcification

P Yang, L Troncone, ZM Augur, SSJ Kim, ME McNeil… - Bone, 2020 - Elsevier
Vascular calcification is associated with atherosclerosis, chronic kidney disease, and
diabetes, and results from processes resembling endochondral or intramembranous …

Pulmonary hypertension: Linking inflammation and pulmonary arterial stiffening

SF Liu, N Nambiar Veetil, Q Li… - Frontiers in …, 2022 - frontiersin.org
Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies
and ultimately leads to right heart failure as the predominant cause of morbidity and …

Research progress of endothelial‐mesenchymal transition in diabetic kidney disease

Y Chen, H Zou, H Lu, H Xiang… - Journal of Cellular and …, 2022 - Wiley Online Library
Renal fibrosis is an important pathological feature of diabetic kidney disease (DKD),
manifested as tubular interstitial fibrosis, tubular atrophy, glomerulosclerosis and damage to …