The cell nucleus contains dozens of subcompartments that separate biochemical processes
into confined spaces. Cajal bodies (CBs) were discovered more than 100 years ago, but …

Metazoan replication-dependent (RD) histone genes encode the only known cellular
mRNAs that are not polyadenylated. These mRNAs end instead in a conserved stem-loop …

The Cajal body, originally identified over 100 years ago as a nucleolar accessory body in
neurons, has come to be identified with nucleoplasmic structures, often quite tiny, that …

Non-polyadenylated mRNAs of replication-dependent histones (RDHs) are synthesized by
RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with …

Polysumoylation is a crucial cellular response to stresses against genomic integrity or
proteostasis. Like the small ubiquitin-like modifier (SUMO)-targeted ubiquitin ligase RNF4 …

Cajal bodies are nuclear subdomains that are involved in maturation of small
ribonucleoproteins and frequently associate with small nuclear RNA and histone gene …

From their initial identification as 'nucleolar accessory bodies' more than a century ago, the
relationship between Cajal bodies and nucleoli has been a subject of interest and …

This review summarizes the current understanding of the role of nuclear bodies in regulating
gene expression. The compartmentalization of cellular processes, such as ribosome …

Nuclear bodies are protein-and RNA-containing structures that participate in a wide range of
processes critical to genome function. Molecular self-organization is thought to drive nuclear …

The majority of the mammalian genome is transcribed by RNA polymerase II, yielding a vast
amount of noncoding RNA (ncRNA) in addition to the standard production of mRNA. The …