Abstract α, α-Bisphosphonates (BPs) are well established in the treatment of bone diseases
such as osteoporosis and Paget's disease. Their successful application originates from their …

Zoledronic acid (ZA) is one of the most important and effective class of anti-resorptive drug
available among bisphosphonate (BP), which could effectively reduce the risk of skeletal …

Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently
above 85% due to huge improvements in treatment. However, 15-20% of children still …

Genetic lesions predisposing to pediatric B-cell acute lymphoblastic leukemia (B-ALL) arise
in utero, generating a clinically silent pre-leukemic phase. We here reviewed the role of the …

Simple Summary B cells are an essential component of the immune system and develop in
the bone marrow microenvironment. B-cell development is tightly regulated by the stromal …

B-cell acute lymphoblastic leukemia (B-ALL) occurs most commonly in children, whereas
chronic myeloid leukemia is more frequent in adults. The myeloid bias of hematopoiesis in …

In recent decades, the conduct of uniform prospective clinical trials has led to improved
remission rates and survival for patients with acute myeloid leukaemia and acute …

In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific
microenvironment. How B cells functionally influence osteoclasts and bone architecture is …

Parthenolide (PTL or PAR) was first isolated from Magnolia grandiflora and identified as a
small molecule cancer inhibitor. PTL has the chemical structure of C15H20O3 with …

Leukemia cells reciprocally interact with their surrounding bone marrow microenvironment
(BMM), rendering it hospitable to leukemia cell survival, for instance through the release of …