Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Ketamine is an effective antidepressant, but there is substantial variability in patient
response and the precise mechanism of action is unclear. Neuroimaging can provide …

Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD)
is necessary. This study used Bayesian adaptive randomization to determine the optimal …

Background Whether cortical excitation and inhibition functions differ between patients with
treatment-resistant depression (TRD) and strong suicidal ideation (SI) and healthy subjects …

The glutamatergic modulator ketamine is associated with changes in sleep, depression, and
suicidal ideation (SI). This study sought to evaluate differences in arousal-related sleep …

Since 2018, significant advances have been made to treat major depression and
treatmentresistant major depression (TRD). These include the FDA approvals of esketamine …

Background: Repetitive transcranial magnetic stimulation (rTMS) has attracted attention for
treating treatment-resistant major depressive disorder (MDD) because of its effectiveness …

An influential hypothesis holds that depression is related to a neural excitation/inhibition
imbalance, but its role in the treatment of depression remains unclear. Here, we show that …