Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Semaphorins were originally identified as axon-guidance molecules that function during
neuronal development. However, cumulative evidence indicates that semaphorins also …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Cancer-associated
fibroblasts (CAFs) are recognized potential therapeutic targets, but poor understanding of …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …

Epithelial tissues robustly respond to internal and external stressors via dynamic cellular
rearrangements. Cell extrusion acts as a key regulator of epithelial homeostasis by …

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and
has the highest propensity to manifest as metastatic disease. Recent characterizations of the …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

Blood vessel networks are typically formed by angiogenesis, a process in which new
vessels form by sprouting of endothelial cells from pre-existing vessels. This process is …

Semaphorins were originally identified as axon guidance factors involved in the
development of the neuronal system. However, accumulating evidence indicates that …