Interindividual variability in mental fatigue-related impairments in endurance performance: a systematic review and multiple meta-regression

J Habay, R Uylenbroeck, R Van Droogenbroeck… - Sports medicine …, 2023 - Springer
Background The negative effect of mental fatigue (MF) on physical performance has recently
been questioned. One reason behind this could lie in the interindividual differences in MF …

Polygenic risk scores in clinical psychology: bridging genomic risk to individual differences

R Bogdan, DAA Baranger… - Annual review of clinical …, 2018 - annualreviews.org
Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …

Single-cell DNA methylation and 3D genome architecture in the human brain

W Tian, J Zhou, A Bartlett, Q Zeng, H Liu, RG Castanon… - Science, 2023 - science.org
Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Identification of common genetic risk variants for autism spectrum disorder

J Grove, S Ripke, TD Als, M Mattheisen, RK Walters… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups

M Mattheisen, J Grove, TD Als, J Martin, G Voloudakis… - Nature Genetics, 2022 - nature.com
Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

NR Wray, S Ripke, M Mattheisen, M Trzaskowski… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Genetic correlates of social stratification in Great Britain

A Abdellaoui, D Hugh-Jones, L Yengo… - Nature human …, 2019 - nature.com
Human DNA polymorphisms vary across geographic regions, with the most commonly
observed variation reflecting distant ancestry differences. Here we investigate the …

Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations

SM Smith, LT Elliott, F Alfaro-Almagro, P McCarthy… - elife, 2020 - elifesciences.org
Brain imaging can be used to study how individuals' brains are aging, compared against
population norms. This can inform on aspects of brain health; for example, smoking and …

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

WD Hill, NM Davies, SJ Ritchie, NG Skene… - Nature …, 2019 - nature.com
Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing)
multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 …

An atlas of gene regulatory elements in adult mouse cerebrum

YE Li, S Preissl, X Hou, Z Zhang, K Zhang, Y Qiu… - Nature, 2021 - nature.com
The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …