Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Although glutamate was first hypothesized to be involved in the pathophysiology of
schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

The kynurenine (KYN) pathway is postulated to play various roles in immune system
dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the …

Autism spectrum disorders are neurodevelopmental disorders characterized by two core
symptoms; impaired social interactions and communication, and ritualistic or repetitive …

Abstract Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor
hypofunction have both been implicated in the pathophysiology of schizophrenia and other …

Disrupted in schizophrenia 1 (DISC1) is well established as a genetic risk factor across a
spectrum of psychiatric disorders, a role supported by a growing body of biological studies …

Psychiatric genetics research, as exemplified by the DISC1 gene, aspires to inform on
mental health etiology and to suggest improved strategies for intervention. DISC1 was …