The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …

It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM),
and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and …

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of
energy homeostasis and body weight. Leptin deficiency or genetic defects in the …

Leptin is the most critical hormone in the homeostatic regulation of energy balance among
those so far discovered. Leptin primarily acts on the neurons of the mediobasal part of …

Several studies show that a significantly stronger association is obvious between increased
body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

The brain controls energy homeostasis and body weight by integrating various metabolic
signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral …

Leptin, the first described adipokine, interplays with hepatic metabolism. The aim of this
review was to summarize available data on the association between leptin and nonalcoholic …