Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the
leading genetic risk factor for Early-Onset AD, prematurely presenting the classic …

Alzheimer's disease (AD) may affect in excess of 90% of individuals with Down syndrome
(DS) after age 60, due to duplication of the APP gene in trisomy of chromosome 21, with …

Goal To examine dementia characteristics, age at onset and associated co‐morbidities in
persons with Down syndrome. Method A total of 77 people with Down syndrome aged 35 …

This briefing paper will assist Primary, Acute and Specialist NHS Trusts in fulfilling their
responsibilities. In this report we summarise the most recent evidence from the UK on the …

This well-established and accessible text has been completely revised in this expanded fifth
edition. Each chapter has been updated, often extensively, to reflect current thinking, and an …

Background: People with Down syndrome (DS) are an ultra-high risk population for
Alzheimer's disease (AD). Understanding the factors associated with age of onset and …

Background In the UK, general practitioners/family physicians receive pay for performance
on management of long‐term conditions, according to best‐practice indicators. Method …

Dementia may be more common in older adults with intellectual disability (ID) than in the
general population. The increased risk for Alzheimer's disease in people with Down …

Abstract Objective Individuals with Down syndrome (DS) have an extremely high genetic risk
for Alzheimer's disease (AD), however, the course of cognitive decline associated with …

Individuals with intellectual disability (ID) are now living longer with the majority of
individuals reaching middle and even “old age.” As a consequence of this extended …