Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells
N Ramakrishnan, TM Weaver, LN Aubuchon… - Nature …, 2024 - nature.com
Clinical success with poly (ADP-ribose) polymerase inhibitors (PARPi) is impeded by
inevitable resistance and associated cytotoxicity. Depletion of Amplified in Liver Cancer 1 …
inevitable resistance and associated cytotoxicity. Depletion of Amplified in Liver Cancer 1 …
Contributing factors to the oxidation-induced mutational landscape in human cells
oxoguanine (8-oxoG) is a common oxidative DNA lesion that causes G> T substitutions.
Determinants of local and regional differences in 8-oxoG-induced mutability across …
Determinants of local and regional differences in 8-oxoG-induced mutability across …
Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine
BL Schnable, MA Schaich, V Roginskaya… - Nature …, 2024 - nature.com
Base excision repair is the main pathway involved in active DNA demethylation. 5-
formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are …
formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are …
Hierarchical determinants of the oxidation-induced mutational landscape in human cells.
8-oxoguanine (8-oxoG) is a common oxidative DNA lesion, which causes G> T substitutions
that compose COSMIC single base substitution signature 18 (SBS18) in human cancers …
that compose COSMIC single base substitution signature 18 (SBS18) in human cancers …
Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β
Single-strand breaks (SSBs) are one of the most prevalent forms of DNA damage found in
the chromatinized genome and are repaired by direct single-strand break repair (SSBR) or …
the chromatinized genome and are repaired by direct single-strand break repair (SSBR) or …
Single-molecule studies of thymine DNA glycosylase interacting with DNA
BL Schnable - 2024 - search.proquest.com
Base excision repair (BER) is suggested to be the main pathway involved in oxidative DNA
demethylation. One such oxidized moiety, 5-formylctyosine (5fC), is recognized and …
demethylation. One such oxidized moiety, 5-formylctyosine (5fC), is recognized and …