Control of tumor-associated macrophage responses by nutrient acquisition and metabolism
Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …
TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective
The immune system responds to cancer in two main ways. First, there are prewired
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
The two T cell inhibitory receptors PD-1 and TIM-3 are co-expressed during exhausted T cell
differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion …
differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion …
Low-dose radiotherapy reverses tumor immune desertification and resistance to immunotherapy
FG Herrera, C Ronet, M Ochoa de Olza, D Barras… - Cancer discovery, 2022 - AACR
Developing strategies to inflame tumors is critical for increasing response to immunotherapy.
Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell …
Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell …
Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases
KM Sullivan, X Jiang, P Guha, C Lausted, JA Carter… - Gut, 2023 - gut.bmj.com
Objective Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive
cellular therapy have had limited success in patients with microsatellite stable colorectal …
cellular therapy have had limited success in patients with microsatellite stable colorectal …
Multi-omics characterization of the 4T1 murine mammary gland tumor model
Background: Tumor models are critical for our understanding of cancer and the development
of cancer therapeutics. The 4T1 murine mammary cancer cell line is one of the most widely …
of cancer therapeutics. The 4T1 murine mammary cancer cell line is one of the most widely …
An in situ hydrogel-mediated chemo-immunometabolic cancer therapy
Metabolic reprogramming of the tumor microenvironment (TME) and poor immunogenicity
are two of the challenges that cancer immunotherapies have to overcome for improved …
are two of the challenges that cancer immunotherapies have to overcome for improved …
Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell–cold solid tumors
B Belmontes, DV Sawant, W Zhong, H Tan… - Science translational …, 2021 - science.org
Therapeutic approaches are needed to promote T cell–mediated destruction of poorly
immunogenic,“cold” tumors typically associated with minimal response to immune …
immunogenic,“cold” tumors typically associated with minimal response to immune …
Harnessing the predictive power of preclinical models for oncology drug development
Recent progress in understanding the molecular basis of cellular processes, identification of
promising therapeutic targets and evolution of the regulatory landscape makes this an …
promising therapeutic targets and evolution of the regulatory landscape makes this an …
Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth
D Doleschel, S Hoff, S Koletnik, A Rix, D Zopf… - Journal of Experimental …, 2021 - Springer
Background Patients with advanced colorectal cancer (CRC) have a poor prognosis.
Combinations of immunotherapies and anti-angiogenic agents are currently being …
Combinations of immunotherapies and anti-angiogenic agents are currently being …