Cutaneous melanoma: From pathogenesis to therapy

GC Leonardi, L Falzone, R Salemi… - International …, 2018 - spandidos-publications.com
In less than 10 years, melanoma treatment has been revolutionized with the approval of
tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to …

UV radiation and the skin

J D'Orazio, S Jarrett, A Amaro-Ortiz, T Scott - International journal of …, 2013 - mdpi.com
UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …

European evidence-based consensus: inflammatory bowel disease and malignancies

V Annese, L Beaugerie, L Egan… - Journal of Crohn's …, 2015 - academic.oup.com
The global prevalence of cancer is increasing, largely as more patients are living into old
age. Therefore, gastroenterologists caring for patients with inflammatory bowel disease [IBD] …

Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation

A Amaro-Ortiz, B Yan, JA D'Orazio - Molecules, 2014 - mdpi.com
Being the largest and most visible organ of the body and heavily influenced by
environmental factors, skin is ideal to study the long-term effects of aging. Throughout our …

International trends in the incidence of malignant melanoma 1953–2008—are recent generations at higher or lower risk?

F Erdmann, J Lortet‐Tieulent, J Schüz… - … journal of cancer, 2013 - Wiley Online Library
The incidence of cutaneous malignant melanoma has steadily increased over the past 50
years in predominately fair‐skinned populations. This increase is reported to have leveled …

Skin cancer and new treatment perspectives: A review

MCF Simoes, JJS Sousa, AACC Pais - Cancer letters, 2015 - Elsevier
Skin cancers are by far the most common malignancy of humans, particularly in the white
population. The growing incidence of cutaneous malignancies has heralded the need for …

Melanoma: epidemiology, risk factors, pathogenesis, diagnosis and classification

M Rastrelli, S Tropea, CR Rossi, M Alaibac - In vivo, 2014 - iv.iiarjournals.org
This article reviews epidemiology, risk factors, pathogenesis and diagnosis of melanoma.
Data on melanoma from the majority of countries show a rapid increase of the incidence of …

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

D Mitra, X Luo, A Morgan, J Wang, MP Hoang, J Lo… - Nature, 2012 - nature.com
People with pale skin, red hair, freckles and an inability to tan—the 'red hair/fair
skin'phenotype—are at highest risk of developing melanoma, compared to all other …

Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease

MD Long, CF Martin, CA Pipkin, HH Herfarth… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) are at risk for
certain malignancies. We aimed to determine the risk of melanoma and nonmelanoma skin …

[HTML][HTML] The epidemiology of UV induced skin cancer

BK Armstrong, A Kricker - Journal of photochemistry and photobiology B …, 2001 - Elsevier
There is persuasive evidence that each of the three main types of skin cancer, basal cell
carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma, is caused by sun …