Diabetic nephropathy as a deleterious complication of diabetes mellitus and an important
cause of end-stage renal failure is characterized by changes in the molecular and cellular …

Physiological studies in leaky epithelia, like kidney proximal tubules and the small intestine,
have documented water transport via both transcellular and paracellular pathways. The …

Aim Claudin‐15 is mainly expressed in the small intestine and indirectly involved in glucose
absorption. Similar to claudin‐2 and‐10b, claudin‐15 is known to form a paracellular …

Tight junctions are macromolecular structures that traverse the space between adjacent
cells in epithelia and endothelia. Members of the claudin family are known to determine tight …

The paracellular pathways in renal tubular epithelia such as the proximal tubules, which
reabsorb the largest fraction of filtered solutes and water and are leaky epithelia, are …

In 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water
flow into the canalicular conduit is in response to an osmotic, not a hydrostatic, gradient …

To provide insight into claudin (Cldn) tight junction (TJ) protein contributions to branchial salt
secretion in marine teleost fishes, this study examined cldn-10 TJ protein isoforms of a …

Epithelia separate apical and basal compartments, and movement of substances via the
paracellular pathway is regulated by tight junctions. Claudins are major constituents of tight …

Atomistic Molecular Dynamics (MD) simulations provide numerous insights into the process
whereby water is driven through a narrow nanopore (diameter on the order of a few water …

AIM: Claudin-15 is mainly expressed in the small intestine and indirectly involved in glucose
absorption. Similar to claudin-2 and-10b, claudin-15 is known to form a paracellular channel …