IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and
inflammatory response but also affects hematopoiesis, metabolism, and organ development …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

The propagation of embryonic stem (ES) cells in an undifferentiated pluripotent state is
dependent on leukemia inhibitory factor (LIF) or related cytokines. These factors act through …

Signal transducer and activator of transcription (STAT) proteins have been shown to mediate
biological actions in response to cytokines. Stat3, a member of the STAT family, is activated …

Members of the IL-6 cytokine family are involved in a variety of biological responses,
including the immune response, inflammation, hematopoiesis, and oncogenesis by …

We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a
new member of the family of soluble defense collagens, in hematopoiesis and immune …

Ten years have passed since the molecular cloning of interleukin 6 (IL-6) in 1986. IL-6 is a
typical cytokine, exhibiting functional pleiotropy and redundancy. IL-6 is involved in the …

OBJECTIVE Insulin resistance is a major characteristic of type 2 diabetes and is causally
associated with obesity. Inflammation plays an important role in obesity-associated insulin …